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. 2019 Feb 4;9:1914. doi: 10.3389/fphys.2018.01914

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Copyright © 2019 Haumann, Camara, Gadicherla, Navarro, Boelens, Blomeyer, Dash, Boswell, Kwok and Stowe.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Changes in buffer [Ca²⁺]_e (A), matrix pH_m (B), and ΔΨ_m (C) over time after adding 40 μM CaCl₂ (210 s) at extra-mitochondrial pH_e 7.6, 7.15, and 6.9 with or without 1 μM Ru360 (300 s) to inhibit additional mCa²⁺ uptake via MCU. Note the rapid fall in [Ca²⁺]_e due to fast mCa²⁺ uptake via the MCU and the following slow rise in [Ca²⁺]_e (Ca²⁺ efflux) (A), slow decline in pH_m (B), and slow depolarization of ΔΨ_m (C) at pH 6.9 (each line = mean of 3–4 replicates from 12 guinea pig hearts for each fluorescence measurement). Note in the pH 6.9 medium the faster rate of mCa²⁺ efflux (A) over time when MCU was blocked, and the faster declines in pH_m (B) and ΔΨ_m (C) over time when MCU was not blocked.