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. 2019 Feb 4;9:1914. doi: 10.3389/fphys.2018.01914

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Copyright © 2019 Haumann, Camara, Gadicherla, Navarro, Boelens, Blomeyer, Dash, Boswell, Kwok and Stowe.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Change in pH_m, measured with BCECF, as a function of time after adding DNP and CaCl₂ in the absence (A,B) or presence (C,D) of OMN. Note that except for 100 μM DNP, neither DNP nor added CaCl₂ altered pH_m in the absence of OMN (A,B). However, in the presence of OMN (C,D) graded decreases of ΔΨ_m by DNP caused a graded increase in matrix acidity that was further increased in the presence of added CaCl₂ (C,D). Buffer pH = 7.15. Data obtained from 10 hearts with 3–4 replicates per heart. For P < 0.05: ^∗after DNP vs. before DNP; ^†late (700 s) vs. early (215 s) after adding CaCl₂.