Table 1.
Construct name | ECD interface | Substitutions |
---|---|---|
GABAAR β3-cryst | β3(+)β3(−) | Substitute ICD (346–396) for SQPARAA |
GABAAR β3 C1 | β3(+)α1(−) | β3-cryst + Y87F,Q89R,G152T |
GABAAR β3 C1 N66D | β3(+)α1(−) | C1 + N66D |
GABAAR β3 C1 A70T | β3(+)α1(−) | C1 + A70T |
GABAAR β3 C1 F87Y | β3(+)α1(−) | β3-cryst + Q89R,G152T |