Figure 8.

SRC promotes YAP/TAZ activity through multiple downstream pathways. Shown is a model that summarizes our findings in the context of what has been previously reported about SRC regulation of YAP/TAZ. Our findings (orange box) show that SRC-mediated repression of LATS promotes YAP/TAZ activity and drives tumor growth and metastasis and that GIT1 is an important SRC effector that regulates LATS. The gray box indicates the core Hippo kinase cascade. The other known mechanisms of SRC regulation of YAP and TAZ include direct phosphorylation (blue box) (I), Hippo-independent mechanisms (green box) (II), and activation of pathways that repress LATS (red box) (III).