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. 2018 Dec 17;294(7):2340–2352. doi: 10.1074/jbc.RA118.004253

Figure 3.

Figure 3.

NAC pretreatment reduces browning in white adipose tissue in response to β3-AR stimulation. A, total body weight of C57/Bl6 mice pretreated for 1 week with either water or NAC (1 g/liter solution) followed by 10 days of injection with either vehicle or 1 μg of CL316,246/g of body weight. B and C, IWAT, GWAT, and BAT weight (normalized to total body weight) in response to the different treatment regimens in C57/Bl6 mice (B) and relative mRNA expression of UCP1, PGC1α, COX4, and ATP6 in IWAT (C) (n = 10/group; *, p < 0.05; **, p < 0.01). D and E, relative UCP1 (D) and COX4 (E) protein expression and representative blots in IWAT (n = 5/group; *, p < 0.05; **, p < 0.01; ****, p < 0.0001). Error bars represent S.E. ns, not significant; Veh, vehicle.