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. 2019 Feb 18;15(2):e8503. doi: 10.15252/msb.20188503

Figure 2. Analysis of protein and transcript expression levels within and across tissues.

Figure 2

  1. Distribution of global transcript and protein abundance in all tissues. It is apparent that the dynamic range of protein expression (iBAQ scale) exceeds that of mRNA expression (FPKM scale; see Appendix Fig S10 for the corresponding plot for RNA and protein copy numbers).
  2. Protein‐to‐mRNA abundance plot for brain tissue. The slope of the regression line indicates that high‐abundance mRNAs give rise to more protein copies per mRNA than low‐abundance mRNAs.
  3. Ranked abundance plot of proteins and transcripts in human heart. While the 10 most abundant transcripts cover almost 70% of all transcripts in this tissue, the corresponding proteins only represent about 20% of the total protein.
  4. Analysis of the number of genes that are shared among the 100 most abundant transcripts and proteins. Regardless of the tissue, the fraction of shared genes rarely exceeds 20%.
  5. Correlation analysis of protein‐to‐RNA abundance (in log10 scale) across tissues, resulting in almost 90% positive correlations. The proteins highlighted in the next panel are marked.
  6. Examples for proteins that show high (SYK, left panel) or no (EIF4A3, right panel) correlation of protein/RNA ratios across tissues. While the former indicates that different tissues express different quantities of SYK, EIF4A3 expression appears to be similar in all tissues.