Table 1.
Kinetic properties of human ALDH1A1, ALDH2 and ALDH3A1 towards oxidation of aldehydes in this study.
| Entry | Com‐ | ALDH1A1 | ALDH2 | ALDH3A1 | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| pound |
V
max
[nmol min−1 μg−1] |
K
M
[mm] |
V max/K M |
V
max
[nmol min−1 μg−1] |
K
M
[mm] |
V max/K M |
V
max
[nmol min−1 μg−1] |
K
M
[mm] |
V max/K M | |
| 1 | 2 | 1.22±0.09 | 0.16±0.03 | 7.9 | 0.09±0.01 | 0.03±0.01 | 2.7 | 2.81±0.03 | 1.87±0.06 | 1.5 |
| 2 | 3 a | 1.10±0.18 | 0.28±0.12 | 3.9 | 0.30±0.02 | 0.64±0.12 | 0.47 | 0.89±0.03 | 1.78±0.11 | 0.5 |
| 3 | 3 b | 1.42±0.17 | 0.26±0.08 | 5.5 | 0.19±0.01 | 0.12±0.01 | 1.5 | 1.51±0.10 | 0.99±0.13 | 1.5 |
| 4 | 4 a | 1.08±0.07 | 0.03±0.01 | 33.9 | 0.67±0.01 | 0.13±0.01 | 4.9 | 1.87±0.03 | 1.19±0.06 | 1.5 |
| 5 | 4 b | 0.98±0.02 | 0.03±0.01 | 28.7 | 0.53±0.01 | 0.07±0.01 | 6.8 | 2.22±0.18 | 1.10±0.18 | 2.0 |
| 6 | 5 | 1.36±0.08 | 0.04±0.01 | 33.3 | 0.32±0.02 | 0.02±0.01 | 19.6 | 1.6±0.13 | 0.18±0.03 | 8.7 |
| 7 | 6 | 1.5±2.68 | 0.10±0.24 | 14.6 | 0.27±0.01 | 0.03±0.01 | 7.4 | 0.03±0.01 | 0.02±0.01 | 1.7 |