Table 4.
Final model parametersa for the exposure-response of disulfiram on cell-associated unspliced (CA-US) HIV-1 RNA.
| Pharmacodynamic Parameters | Estimate (RSE, %a) |
|---|---|
| λbase (copies/106 CD4+ T cells) | 103 (13.6) |
| OVDP | 0.282 (6.1) |
| AUC50 (mg*h/L) | 1600 (8.9) |
| Emax (fraction increase) | 78 (13.6) |
| Gamma | 15.3 (11.5) |
| BSV (Baseline) (CV %) | 154 (16.2) |
| BSV (Overdispersion) (CV %) | 54 (24.0) |
| BSV (AUC50) (CV %) | 38 (87.7) |
| BSV (Emax) (CV %) | 47 (49.4) |
Abbreviations: λBase = mean baseline count of HIV-1 RNA, OVDP= overdispersion parameter describing the negative binomial function, AUC = area under the curve; DSF = disulfiram; Emax = concentration at which maximum efficacy observed; Gamma = parameter to account for shape; BSV = between-subject variability); CV = coefficient of variation.
a
Obtained by nonparametric bootstrap with 100 samples.