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Papillary hyperplasia of the bronchiolar epithelium at alveolar duct bifurcation. Serial sections of papillary hyperplasia at the terminal bronchus in a p53+/− mouse 11 months post-initial exposure to rMWCNTs. This rare pathology was captured in the IHC T cell marker CD3 and B cell marker CD45R sections. Arrows indicate location of papillary attachment to the bronchiole wall (scale bars equal 200 μm, inset scale bars equal 50 μm).
