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. Author manuscript; available in PMC: 2020 Feb 1.
Published in final edited form as: J Neurochem. 2018 Dec 20;148(4):531–549. doi: 10.1111/jnc.14629

Figure 6: Non-canonical CREB modulators affect excitotoxic necrosis.

Figure 6:

Average number of degenerating head neurons per animal in different developmental stages, comparing the original excitotoxicity strain (glt-3;nuIs5) to a similar strain where a mediator of the non canonical pathway is eliminated: B) Testing the CaMK-I/IV homolog CMK-1 (cmk-1;glt-3;nuIs5); C) Testing the SIK homolog AAK-2 (glt-3;nuIs5;aak-2); D) Testing the CREB cofactor CRTC homolog CRTC-1 (crtc-1;glt-3;nuIs5). All statistical comparisons, at each life-stage used one-way ANOVAs, where * indicates p≤0.05; ** indicates p≤0.01; *** indicates p≤0.001.