Figure 1.

Direct immune regulation of lymphoid cells by SPMs and eicosanoids during inflammation. Lipid mediators and inflammation are conceptually and functionally closely intertwined. Upon cellular activation, lipid mediators are synthesized de novo locally and rapidly metabolized at the site of inflammation to modulate the immune response. SPMs and eicosanoids can directly inhibit or promote lymphocytes functions as depicted by symbols representing migration, proliferation, antibody production, cytotoxicity, activation, differentiation, development and cytokine production. Eicosanoids and SPMs mediate intracellular communication in a cell -specific approach.