Table 2.
Comparison of effects of alfuzosin and placebo on rectoanal pressures
| Healthy women | Constipated patients | |||
|---|---|---|---|---|
| Parameter | Placebo | Alfuzosin | Placebo | Alfuzosin |
| Anal resting pressure | −12 (−31, −4) | −32 (−43, −18)a | −21 (−29, −10) | −32 (−50, −17)a |
| Anal squeeze pressure | −31 (−47, 11) | −5 (−39, 4) | −29 (−51, 10) | −20 (−32, 3) |
| Anal squeeze increment | −3 (−37, 3) | 20 (6, 38) | 3 (−27, 22) | 6 (−3, 32) |
| Simulated evacuation - rectal pressure | 2 (−7, 5) | 2(−1, 11) | 0 (−10, 3) | 3 (−5, 11) |
| Simulated evacuation - anal pressure | −16 (−23, −8) | −29 (−37, −12) | −15 (−23, −3) | −28 (−43, −22)a |
| Simulated evacuation - anal relaxation | 9 (−3, 16) | −20 (−27, 19) | −7 (−20, 8) | −11 (−22, 5) |
| Simulated evacuation - rectoanal gradient | 19 (9, 28) | 26 (16, 40) | 16 (1, 34) | 27 (14, 47) |
| Rectal balloon expulsion time | 0 (−2, 0) | −1 (−5, 0) | 0 (−17, 0) | −2 (−13, 0) |
Values are Difference (After – Before Drug) in mmHg except for balloon expulsion time (seconds) and anal relaxation during simulated evacuation (%). Values are medians (interquartile range)
a
p ≤ 0.01 versus corresponding difference for placebo