Table 6. Summary of the medical treatment of heparin induced thrombocytopenia (HIT) using direct thrombin inhibitors.

Medication	Initial infusion dose (µg/kg/min)	Treatment duration (days)	Target ACT, lower range (seconds)	Target ACT, upper range (seconds)	Target aPTT, lower range (seconds)	Target aPTT, upper range (seconds)
Argatroban, median [IQR]	0.2 [0.2–0.7]	11 [8–36]	165 [163–168]**	190 [185–195]**	50 [49–53]	60 [60–60]
Hirudin derivatives (all), median [IQR]	5.0 [3.5–6.5]**	4 [3–5]**	180 [165–190]	220 [210–260]	45 [45–45]*	50 [50–50]*
Bivalirudin, median [IQR]	8.0 [8.0–8.0]*	2 [2–2]*	190 [185–195]**	260 [240–280]**	N/A	N/A
Lepirudin, median [IQR]	2.0 [2.0–2.0]*	6 [6–6]*	150 [150–150]*	200 [200–200]*	45 [45–45]*	50 [50–50]*

*, based on a single case report; **, based on two case reports. IQR, interquartile range; ACT, activated clotting time; aPTT, activated partial thromboplastin time.