Table 1.
Clinical studies reporting prevalence/incidence of atrial fibrillation in HIV‐1 patients
| Study (Year) | Study design | Population | Male (%) | Age | FU (years) | Prevalence/incidence of AF | Other findings | NOS |
|---|---|---|---|---|---|---|---|---|
| Elnahar (2012) 17 | Retrospective | 780 HIV‐1 patients | 67.5a | 56.8 ± 9.4a | 3 | 40/780 (5.13%) developed AF. | 47% of HIV‐1 patients who developed AF had CD4+ T cell count <250 cells ml−1 vs. 20% of controls (P = 0.017) | 7 |
| Hsu (2013) 18 | Registry | 30 533 HIV‐1 infected veterans | 97.2 | 53.6 ± 11.4 | 6.8 | 780 incident cases (2.55%): 641 AF and 139 AFL. Incidence rate: 3.6 per 1000 person‐years (95% CI 3.4–3.9). | CD4+ T cell count (<200 vs. >350 cells ml−1; HR: 1.4; 95% CI: 1.1–1.8; P = 0.018) and viral load >100 000 vs. <500 copies ml−1; HR: 1.7; 95% CI: 1.2–2.4; P = 0.002) were associated to incident AF. | 7 |
| Sanders (2018) 19 | Retrospective | 5052 HIV‐1 patients | 82.5 | 48.2 ± 11.6 | 16 | 101 confirmed AF/AFL cases (2.00%) | OR 1.98, 95% CI 1.21–3.25 for nadir CD4+ T cell count <200 cells ml−1 for AF/AFL. No association between HIV viral load and AF/AFL (OR 1.03, 95% CI 0.86–1.24) | 7 |
a
Values refer to 40 patients developing AF
AF, atrial fibrillation; AFL, atrial flutter; CI, confidence interval; FU, follow‐up; HR, hazard ratio; NOS, Newcastle–Ottawa quality assessment scale; OR, odds ratio