Figure 5.

Boxplot with 10–90 percentile whiskers comparing simulations of the standard bodyweight‐based dose and a dose based on the starting dose model. (A) Simulated predose concentrations. The median tacrolimus C₀ in the bodyweight‐based dose group was 13.9 ng ml^–1, and in the model‐based dose group 12.9 ng ml^–1. (B) Simulated AUCs. The median tacrolimus AUC in the bodyweight‐based dose group was 298.5 ng h ml^–1, and in the model‐based dose group 277.9 ng h ml^–1. AUC, area under the curve