Table 5.
Predictive performance of most accurate selected limited sampling strategies predicting tacrolimus exposure in adult kidney transplant recipients
| Sampling times | Precision | Bias | % AUClss within 15% AUCint | r2 | ||
|---|---|---|---|---|---|---|
| RMSE (%) | MAPE (%) | MPE (ng h ml–1) | MPPE (%) | |||
| 0 h | 19.5 | 20.4 | –0.9 | 0.5 | 59.7 | 0.61 |
| 0, 2 h | 9.2 | 7.3 | –3.2 | –2.4 | 92.5 | 0.89 |
| 0, 1, 4 h | 6.0 | 5.2 | –2.3 | –1.5 | 100.0 | 0.95 |
| 0, 1, 2, 4 h | 5.1 | 4.2 | –2.5 | –1.8 | 100.0 | 0.96 |
RMSE, relative root mean squared prediction error; MAPE, mean absolute percentage prediction error; MPE, mean prediction error; MPPE, mean percentage prediction error; AUClss, tacrolimus area under the concentration curve predicted by Bayesian forecasting; AUCint, tacrolimus area under the concentration curve calculated from the final pharmacokinetic model with intensive serial sampling; r2, coefficient of determination between AUClss and AUCint