Table 3. Non-vitamin K antagonist oral anticoagulant.

	Dabigatran	Rivaroxaban	Apixaban	Edoxaban
Mechanism	Oral direct thrombin inhibitor	Oral direct factor Xa inhibitor	Oral direct factor Xa inhibitor	Oral direct factor Xa inhibitor
Dose	150 mg twice daily	20 mg once daily	5 mg twice daily	60 mg once daily
Dose reduction in selected patients	110 mg twice daily if > 80 yrs, GFR 30-50, concomitant use of verapamil	Rivaroxaban 15 mg once daily if GFR 30-49	Apixaban 2.5 mg twice daily if at least 2 of age ≥ 80 years, body weight ≤ 60 kg or serum creatinine level ≥ 1.5 mg/dL (133 µmol/L), or if GFR 15-30.	30 mg once daily if GFR 15–49 mL/min, weight ≤ 60 kg, concomitant use of verapamil or quinidine or dronedarone

GFR: glomerular filtrate rate (mL/min per m²).