Skip to main content
. 2019 Feb 12;10:73. doi: 10.3389/fendo.2019.00073

Figure 3.

Figure 3

Knock down of LRP6 attenuated PA-induced IR in LO2 hepatocytes. LO2 hepatocytes were infected with Ad-Si-LRP6 to knock down LRP6 protein expression. (A) LRP6 protein expression was reduced upon Ad-Si-LRP6 infection. *p < 0.05 vs. control (n = 6). (B) Western blot analysis of insulin signal pathway following LRP6 knock down. (C) Quantification of western blot results. Data were normalized to control treatment for each protein. *p < 0.05 vs. no-PA treatment control; #p < 0.05 vs. PA treatment group (n = 6). (D) LRP6 knock down enhanced glucose uptake in PA treated LO2 hepatocytes in the presence of insulin. *p < 0.05 vs. no-insulin stimulated control; #p < 0.05 vs. PA treatment group (n = 6).