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Knock down of LRP improved insulin sensitivity through activation of autophagy in LO2 hepatocytes. (A,B) Western blot analysis (A) and quantification (B) showing that LRP6 knock down induced autophagy activation in LO2 hepatocytes (n = 6). (C,D) Representative images and statistical data of LO2 hepatocytes expressing GFP-LC3 via adenovirus infection upon on control, PA and/or Ad-Si-LRP6 treatment. *p < 0.05 vs. no-PA treatment group; #p < 0.05 vs. PA treatment group.
