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. 2019 Feb 12;10:44. doi: 10.3389/fpsyt.2019.00044

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Copyright © 2019 Barredo, Aiken, van 't Wout-Frank, Greenberg, Carpenter and Philip.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Functional connectivity strength between lateral pars orbitalis and midline cognitive control regions tracks suicidality, and cortical thickness is predictive of significant connectivity relationships. (A) left lateral pars orbitalis ROI (left) was more strongly connected to ROIs in bilateral a24, right d32, and right 9m (all p-FDR < 0.05), in those with more severe suicidality (middle). Connectivity strength of right a24 to bilateral orbitalis also tracks suicidality (p-FDR < 0.05) (right). (B) reward and cognitive control networks overlap in perigenual cortex. (C) cortical thickness in a24 predicts the relationship between suicidality and orbitalis-to-a24 connectivity in the ipsilateral hemisphere. Right d32 thickness predicted the relationship between a24-to-left lateral orbitalis connectivity and suicidality.