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. 2019 Feb 12;13:40. doi: 10.3389/fncel.2019.00040

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Copyright © 2019 Roselló-Busquets, de la Oliva, Martínez-Mármol, Hernaiz-Llorens, Pascual, Muhaisen, Navarro, del Valle and Soriano.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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MβCD treatment accelerates motor and sensory functional recovery following sciatic nerve injury. (A–D) Electrophysiological results after nerve injury in mice treated with vehicle or with MβCD. Results of CMAP amplitude (A,B) and latency (C,D) recorded in TA and PL at 14, 21, 25, 28, and 33 dpi. Data are shown as the mean and SEM (bars). ^∗p < 0.05 with two-way Anova and Bonferroni test. (E,F) Pinprick test results to analyze sensory reinnervation in the hindpaw pad C (E) and 4th toe (F). Results show the percentage of animals with positive response in each area in the groups treated with vehicle or MβCD. p < 0.05 Mantel–Cox test indicate differences in the proportion of mice with reinnervation.