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Deletion of Shank3 reduces mGluR5 expression in the striatum. mGluR5, homer1 and NR2b were reduced in the striatum from Shank3B−/− mice. Each lane was loaded with 3 μg of protein, with β-actin as a loading control and normalized to wild-type levels. *p < 0.05, **p < 0.01, two-tailed t-test; all data are presented as the means ± s.e.m.; n = 3 samples per group.
