Table 4.
Fecal microbiota transplantation (FMT) for chronic constipation.
| References | Study | Interventions (n) | Controls (n) | Follow-up Period | Outcome |
|---|---|---|---|---|---|
| Borody et al. (42) | Case series | 4 | – | 28 months | Defecation frequency↑ |
| Andrews et al. (43) | Case report | 1 | – | 18 months | Defecation frequency↑ Melanosis coli disappeared |
| Ge et al. (44) | Case series | 6 | – | 12 weeks | Defecation frequency↑ (P < 0.05) Stool consistency ↓ (P < 0.05) Colonic transit time ↓ (P < 0.05) |
| Tian et al. (45) | RCT | 30 | 30 | 12 weeks | Defecation frequency↑ (p = 0.001) Stool consistency ↓ (P < 0.00001) Colonic transit time ↓ (P < 0.00001) Clinical cure rate ↑ (p = 0.04) Clinical improvement rate ↑ (p = 0.009) |
| Ding et al. (46) | Case series | 52 | – | 24 weeks | Defecation frequency↑ (P < 0.01) Stool consistency ↓ (P < 0.01) Incompleteness of evacuation ↓ (P < 0.01) Colonic transit time ↓ (P < 0.01) |
| Zhang et al. (47) | Case series | 29 | – | 1 year | Complete spontaneous bowel movement, stool consistency, the Wexner constipation scale and constipation symptoms improved |
RCT, Randomized controlled trials.