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. 2019 Feb 12;10:134. doi: 10.3389/fimmu.2019.00134

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Copyright © 2019 Fusade-Boyer, Dupré, Bessière, Khiar, Quentin-Froignant, Beck, Lecollinet, Rameix-Welti, Eléouët, Tangy, Lajoie, Bertagnoli, Vidalain, Gallardo and Volmer.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Evaluation of the antiviral potential of Sephin1 against myxoma virus in vivo. Rabbits were inoculated with 50 plaque-forming units of myxoma virus. Eight rabbits were treated with Sephin1 by oral gavage once daily at a dose of 5 mg/kg. Seven rabbits were administered vehicle only. Myxoma virus DNA was detected by q-PCR from conjonctival swabs performed at the indicated days post-infection. Rabbits exhibiting clinical signs are indicated with an arrow. ^*p < 0.05 by the two-tailed Mann–Whitney test.