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. 2019 Feb 12;10:213. doi: 10.3389/fimmu.2019.00213

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Copyright © 2019 Roider, Ngoepe, Muenchhoff, Adland, Groll, Ndung'u, Kløverpris, Goulder and Leslie.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Increased IL-7/sIL-7 receptor in pediatric slow progressors. Frequency of IL-7R (CD127) expression on CD4 (A) and on central memory CD4 (B) T-cells in PSPN (dark blue; n = 10), PFP (light blue; n = 8), PP (red; n = 8), and uninfected pediatric controls (green; n = 15). (C) Same groups as before but showing frequency of IL-7R expression on CD8 T-cells and (D) frequency of CD4 T-cells double-negative for IL-2R (CD25) and IL-7R (CD127). (E) Ex-vivo plasma levels of IL-7 in pg/ml in PSPN (n = 13, dark blue), PFP (n = 6, light blue), PP (n = 12; red), and pediatric uninfected controls (n = 14; green). (F) Same as in (E) but showing plasma levels of IL-7R (sCD127) in ng/ml in the different groups. For scatterplots, median, and interquartile range are shown. Kruskal-Wallis test was performed and corrected for multiple comparisons.