Table 3.
Proteins origin of the 146 differentially excreted urinary peptides obtained by the comparison between RCAD and healthy patients.
| Protein name | Gene symbol | N° of protein fragments | P-value (adjusted) | Mean fold change |
|---|---|---|---|---|
| Mucin-3a | MUC3A | 1 | 1.10E-05 | −56.9 |
| Collagen alpha-1 (XXVI) chain | COL26A1 | 1 | 1.72E-03 | −11.2 |
| Protein unc-119 homolog A | UNC119 | 1 | 4.95E-03 | −7.05 |
| Collagen alpha-3 (V) chain | COL5A3 | 1 | 7.70E-04 | −6.25 |
| Uromodulin | UMOD | 4 | 4.82E-02 | −5.7 (±2.33) |
| Collagen alpha-1 (XXVII) chain | COL27A1 | 1 | 2.04E-02 | −5.66 |
| Cystatin-A | CSTA | 1 | 5.88E-03 | −3.67 |
| Hemoglobin subunit delta | HBD | 1 | 3.65E-02 | −3.38 |
| Annexin A1 | ANXA1 | 1 | 6.44E-03 | −2.68 |
| Sarcalumenin | SRL | 1 | 1.05E-02 | −2.21 |
| Collagen alpha-1 (XVII) chain | COL17A1 | 1 | 3.14E-03 | −2.03 |
| Ig lambda-2 chain C regions | IGLC2 | 1 | 1.45E-02 | −1.92 |
| Beta-2-microglobulin | B2M | 1 | 1.04E-02 | −1.17 |
| Serum amyloid A protein | SAA1 | 2 | 4.87E-02 | −0.81 (±2.95) |
| Collagen alpha-1 (XI) chain | COL11A1 | 1 | 4.21E-03 | 1.19 |
| Collagen alpha-1 (VIII) chain | COL8A1 | 1 | 3.61E-02 | 1.29 |
| Kininogen-1 | KNG1 | 1 | 1.69E-02 | 1.53 |
| Collagen alpha-1 (I) chain | COL1A1 | 52 | 4.97E-02 | 1.7 (±3.42) |
| Short transient receptor potential channel 4-associated protein | TRPC4AP | 1 | 1.74E-02 | 1.98 |
| Collagen alpha-2 (V) chain | COL5A2 | 3 | 1.67E-02 | 2.23 (±2.9) |
| Collagen alpha-1 (XVI) chain | COL16A1 | 1 | 3.53E-02 | 2.24 |
| Mucin-1 subunit alpha | MUC1 | 1 | 9.90E-03 | 2.4 |
| Ig kappa chain C region | IGKC | 1 | 1.68E-02 | 2.64 |
| Collagen alpha-5 (IV) chain | COL4A5 | 1 | 2.88E-02 | 2.86 |
| Collagen alpha-6 (IV) chain | COL4A6 | 1 | 5.61E-04 | 3 |
| Retinol binding protein 4 | RBP4 | 1 | 7.78E-03 | 3.11 |
| Protein scribble homolog | SCRIB | 1 | 3.51E-02 | 3.15 |
| Collagen alpha-2 (I) chain | COL1A2 | 20 | 4.84E-02 | 3.28 (±6.86) |
| Actin, cytoplasmic 1 | ACTB | 1 | 2.88E-02 | 3.3 |
| Neurosecretory protein VGF | VGF | 1 | 3.80E-02 | 3.45 |
| Collagen alpha-1 (III) chain | COL3A1 | 21 | 4.67E-02 | 3.47 (±4.54) |
| Osteopontin | OPN | 2 | 1.56E-02 | 3.85 (±2.21) |
| Collagen alpha-4 (IV) chain | COL4A4 | 1 | 1.46E-03 | 4 |
| Collagen alpha-1 (II) chain | COL2A1 | 7 | 3.05E-02 | 4.45 (±5.37) |
| Fibrinogen alpha chain | FGA | 2 | 5.87E-03 | 4.79 (±0.48) |
| Ephrin-A1 | EFNA1 | 1 | 5.46E-03 | 5.55 |
| Interleukin-1 receptor-associated | IL-1R | 1 | 1.27E-04 | 43.2 |
| Immunoglobulin kappa variable 4-1 | IGKV4-1 | 1 | 1.88E-04 | 56.7 |
| Gelsolin | GSN | 1 | 1.66E-05 | 105.4 |
| Microfibrillar-associated protein 5 | MFAP5 | 1 | 4.32E-05 | 308.3 |
| Collagen alpha-1 (V) chain | COL5A1 | 2 | 4.36E-02 | 180.32 (±253) |
Proteins origin of the 146 differentially excreted urinary peptides obtained by the comparison between RCAD and healthy patients. An extended detailed version of the table can be found in Supplementary Table 2. Data described the number of significant peptides related to each protein, the lowest observed P-value and the mean fold change (±standard deviation).