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. 2019 Feb 18;9:2193. doi: 10.1038/s41598-019-38668-7

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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High-throughput screening of FXR ligands using FRET-based flow cytometry. (A) working model of the FRET sensor. (B) Mean values of the fifteen strongest hits that increased the FRET+ cells for at least 20%. (C) Representative FACS-plots showing the amount of FRET+ cells after 30 minute treatment with negative control (DMSO), positive control (GW4064) or 10 μM of the top hit avermectin B1a. Numbers indicate the percentages of cells within the FRET gate.