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. 2019 Feb 18;9:2199. doi: 10.1038/s41598-018-37240-z

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Kaplan-Meier survival comparisons of cases with ALK mutation vs non-ALK mutation cases. Kaplan-Meier (overall survival) analysis according to the presence or absence of somatic ALK aberrations in 105 neuroblastoma tumours (a) ALK mutated versus non-ALK mutated cases (b) OS according to MYCN and ALK status (MYCN amplification vs. no amplification; ALK alteration versus no alteration). ALK mutational status does not add prognostic information to the independent clinical parameter MYCN status. Pos, positive for ALK alteration (ALK mutations and/or amplification). Wt, wildtype. OS, overall survival.