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. 2019 Feb 18;9:2220. doi: 10.1038/s41598-019-39440-7

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Antiviral therapy improves pathologic characteristics, especially MVI occurrence. (a) Examples of MVI in antiviral and no antiviral groups, compared to the HBsAg(−) group. (b) MVI occurrence rate in antiviral and no antiviral groups compared to the HBsAg(−) group. (c) Average level of MVI in antiviral and no antiviral groups compared to the HBsAg(−) group. (d) Difference in MVI occurrence rates between antiviral and no antiviral groups stratified by histopathologic inflammation grade (G1/G2/G3). (e) Difference in MVI occurrence rates between antiviral and no antiviral groups among cirrhosis patients. (f) Tumor capsule integrity tare in antiviral and no antiviral groups compared to the HBsAg(−) group. (g) Satellite micronodules rate in antiviral and no antiviral groups compared to the HBsAg(−) group. (h) Difference in serum AFP levels between antiviral and no antiviral groups. (i) Difference in HBV DNA loads between antiviral and no antiviral groups.