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. 2019 Feb 18;9:2217. doi: 10.1038/s41598-018-38452-z

Table 3.

Association analysis between the PXR and CAR SNPs and antituberculosis-drug induced hepatotoxicity.

SNP Genotype†, n case/control PHWE Additive* Dominant* Recessive*
0/0 0/1 1/1 OR (95% CI) P OR (95% CI) P OR (95% CI) P
PXR
   rs7643645 70/73 97/150 36/76 0.785 0.704 (0.539–0.918) 0.010 0.609 (0.405–0.917) 0.017 0.645 (0.405–1.026) 0.064
   rs6785049 65/104 107/137 31/58 0.954 0.972 (0.743–1.271) 0.833 1.208 (0.809–1.804) 0.356 0.677 (0.408–1.123) 0.131
   rs3732357 88/131 97/139 18/29 0.143 1.012 (0.756–1.355) 0.936 1.030 (0.706–1.503) 0.878 0.973 (0.510–1.855) 0.934
   rs3814055 117/174 71/107 15/18 0.416 1.112 (0.823–1.502) 0.489 1.068 (0.732–1.559) 0.731 1.473 (0.707–3.066) 0.301
   rs2472682 71/100 102/149 30/50 0.447 0.950 (0.723–1.248) 0.713 1.001 (0.674–1.487) 0.995 0.835 (0.499–1.395) 0.490
   rs3814057 45/74 110/145 48/80 0.716 1.005 (0.770–1.312) 0.970 1.299 (0.831–2.030) 0.251 0.788 (0.509–1.221) 0.286
   rs2472677 82/133 88/142 33/44 0.230 0.968 (0.740–1.266) 0.811 0.891 (0.607–1.306) 0.552 1.097 (0.651–1.847) 0.729
CAR
   rs6686001 136/194 57/98 10/7 0.818 0.991 (0.704–1.395) 0.958 0.912 (0.614–1.354) 0.648 1.766 (0.619–5.034) 0.288
   rs2307424 59/81 94/150 50/68 0.560 0.937 (0.719–1.221) 0.628 0.884 (0.584–1.337) 0.559 0.957 (0.610–1.502) 0.848
   rs4073054 159/243 41/54 3/2 0.815 1.160 (0.752–1.789) 0.502 1.149 (0.723–1.823) 0.556 1.753 (0.243–12.64) 0.578
   rs3003596 59/90 96/147 48/62 0.560 1.032 (0.788–1.351) 0.818 0.997 (0.661–1.504) 0.989 1.104 (0.692–1.763) 0.677
   rs7530560 75/99 89/146 39/54 0.386 0.986 (0.754–1.289) 0.919 0.917 (0.616–1.366) 0.670 1.086 (0.670–1.760) 0.739
   rs2502805 94/129 82/127 27/43 0.066 0.975 (0.743–1.279) 0.855 0.979 (0.668–1.434) 0.913 0.943 (0.547–1.627) 0.833

†“0” represents the major allele, “1” represents the minor allele.

HWE: Hardy-Weinberg equilibrium. HWE was assessed by the χ2 goodness-of-fit test based on the genotype distributions in this study.

*Adjusted for ethnicity, age, gender, height, weight, smoking, drinking, and HbsAg status. Additive: minor allele homozygotes versus heterozygotes versus major allele homozygotes. Dominant: heterozygotes plus minor allele homozygotes versus major allele homozygotes. Recessive: minor allele homozygotes versus major allele homozygotes plus heterozygotes.