Table 4.
Analyses of derived haplotypes (frequency more than 3%) from seven polymorphisms of PXR with the risk of ATDH.
| Haplotypes† | ATDH group | Non-ATDH group | OR | 95% CI | P value | ||
|---|---|---|---|---|---|---|---|
| n | % | n | % | ||||
| H0000001 | 24 | 5.9 | 26 | 4.4 | 1.362 | 0.767–2.419 | 0.291 |
| H0010001 | 31 | 7.7 | 71 | 11.9 | 0.591 | 0.377–0.927 | 0.021 |
| H0010110 | 36 | 9.0 | 50 | 10.5 | 1.069 | 0.678–1.686 | 0.774 |
| H0100110 | 34 | 8.4 | 59 | 9.9 | 0.806 | 0.514–1.263 | 0.346 |
| H0101000 | 21 | 5.2 | 23 | 3.8 | 1.280 | 0.688–2.383 | 0.435 |
| H0101001 | 16 | 3.9 | 25 | 4.2 | 0.839 | 0.466–1.858 | 0.931 |
| H0110110 | 27 | 6.7 | 31 | 5.1 | 1.315 | 0.768–2.252 | 0.318 |
| H1101001 | 43 | 10.5 | 51 | 8.5 | 1.138 | 0.730–1.776 | 0.568 |
| H1111001 | 16 | 3.9 | 31 | 5.2 | 0.730 | 0.391–1.360 | 0.320 |
†“0” represents the major alleles, “1” represents the minor alleles.
Order of polymorphisms: rs3814055, rs2472677, rs7643645, rs3732357, rs2472682, rs6785049, rs3814057. ATDH: antituberculosis drug-induced hepatotoxicity.