Table 5.
Analyses of derived haplotypes (frequency more than 3%) from six examined polymorphisms of CAR with the risk of ATDH.
| Haplotypes† | ATDH group | Non-ATDH group | OR | 95% CI | P value | ||
|---|---|---|---|---|---|---|---|
| n | % | n | % | ||||
| H001000 | 114 | 28.0 | 169 | 28.4 | 0.946 | 0.714–1.254 | 0.699 |
| H011000 | 47 | 11.7 | 57 | 9.6 | 1.210 | 0.804–1.819 | 0.360 |
| H010011 | 115 | 28.2 | 182 | 30.5 | 0.863 | 0.653–1.141 | 0.300 |
| H111001 | 28 | 6.9 | 33 | 5.5 | 1.239 | 0.735–2.089 | 0.421 |
| H000100 | 76 | 19.0 | 107 | 17.9 | 1.040 | 0.751–1.440 | 0.815 |
| H110011 | 18 | 4.5 | 23 | 3.9 | 1.139 | 0.607–2.135 | 0.686 |
†“0” represents the major alleles, “1” represents the minor alleles.
Order of polymorphisms: rs4073054, rs2307424, rs3003596, rs6686001, rs2502805, rs7530560. ATDH: antituberculosis drug-induced hepatotoxicity.