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. 2019 Feb 12;10:61. doi: 10.3389/fphar.2019.00061

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Copyright © 2019 Zhao, Zhuang, Wang, Zhou, Zhao, Zhu, Pu, Zhang, Yin, Zhao, Wang and Hong.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Mitochondrial morphology and quantity kept stable and propofol inhibited Drp1 colocalization with mitochondria in H9c2 cells during OGD/R injury. (A,D,G,J,K) Mitochondrial (red) morphology and quantity of H9c2 cells kept stable among control group, OGD/R group without propofol and OGD/R group with 20 μM propofol. Scale bar: 25 μm. (B,C) There was a lower fluorescence signal for Drp1 (green) and most Drp1 was collocated with the mitochondria or surrounded them in control group. (E,H) The distribution of Drp1 in OGD/R group with 20 μM propofol was more diffuse than the distribution of it in OGD/R group without propofol. (F) Plenty of Drp1 was collocated with mitochondria or surrounded them in OGD/R group without propofol. (I) Using 20 μM propofol treatment, Drp1 (green) was significantly prevented from cytoplasm to mitochondria during OGD/R injury. The data are presented as the mean ± SD of at least three independent experiments.