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. 2019 Feb 12;13:3. doi: 10.3389/fnint.2019.00003

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Copyright © 2019 Bereiter, Thompson and Rahman.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Systemic administration of letrozole (Ltz, 10 mg/kg, sc) for 4 days reduced ATP-evoked MMemg responses in OvX rats. (A) Example of MMemg activity evoked by intra-TMJ injection of ATP (1 mM, 20 μl) in OvX (upper panel) and OvX + Ltz rats (lower panel). (B) Summary of integrated MMemg activity evoked by ATP in OvX and OvX + Ltz rats. Arrow indicates the time of intra-TMJ ATP stimulation; ^∗∗p < 0.01 versus vehicle, b = p < 0.01 versus OvX + letrozole (OvX + Ltz).