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. 2019 Feb 12;10:100. doi: 10.3389/fneur.2019.00100

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Copyright © 2019 Jin, Wang, Wang, Lian, Zhou, Zhang, Lv, Li, Huang, Cheng, Fei, Liu, Zeng and Zhong.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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NM-MRI and QSM images. (A–C) represent the normal, possibly abnormal, and definitely abnormal SN on NM-MRI, respectively. Nigrosome-1 (N1) could be visualized in the dorsal part of the healthy SN on QSM images (D, arrow). (D–F) represent that N1 was present, indecisively present and absent, respectively. (G,H), a control subject, female, 65 years, neuromelanin was normal (G) and N1 was present (H, arrow) in bilateral SN. (I,J), an ET patient, 59 years, female, neuromelanin was normal (I) and N1 was present (J, arrow) in bilateral SN. (K,L), a de novo PD patient, 75 years, female, neuromelanin was definitely abnormal in unilateral SN (K, arrowhead) and N1 was absent in bilateral SN (L).