Table 1.
Demographic, clinical and laboratory characteristics of cirrhotic patients with (Aspergillus +) or without (Aspergillus −) positive culture of Aspergillus spp
| Variables | Aspergillus + n = 60 |
Aspergillus – n = 148 |
p value |
|---|---|---|---|
| Age (years), mean (SD) | 55.4 (12.6) | 54.7 (11.5) | 0.6 |
| Gender (male), n (%) | 51 (85) | 125 (84) | 0.38 |
| Aetiology of cirrhosis, n (%) | < 0.001 | ||
| Alcohol | 25 (42) | 106 (71) | |
| Viral | 23 (38) | 32 (22) | |
| Other | 12 (20) | 10 (7) | |
| Comorbidities, n (%) | |||
| COPD | 23 (38) | 20 (14) | 0.001 |
| Immunosuppressive treatment | 15 (25) | 22 (15) | 0.08 |
| Ascites | 24 (40) | 47 (32) | 0.82 |
| Life support n (%) | |||
| Mechanical ventilation | 31 (52) | 77 (52) | > 0.99 |
| Catecholamine | 30 (50) | 50 (34) | 0.03 |
| Renal replacement therapy | 13 (22) | 13 (9) | 0.01 |
| Liver support | 7 (12) | 5 (3.4) | 0.02 |
| Laboratory data, mean (SD) | |||
| INR | 2.01 (1.64) | 2.4 (2) | 0.23 |
| Serum bilirubin (µmol/l) | 131 (159) | 151(165) | 0.056 |
| Serum creatinine (µmol/l) | 155 (151) | 149 (131) | 0.98 |
| Serum sodium (mmol/l) | 135 (5.3) | 134 (7.7) | 0.89 |
| Prognostic score, mean (SD) | |||
| Child–Pugh score | 11.2 (2.8) | 10.6 (2.3) | 0.15 |
| MELD score | 21 (11.2) | 22,6 (9.8) | 0.25 |
| SAPS II score | 46 (20) | 44 (19,7) | 0.68 |
| SOFA score | 9.8 (7.3) | 8.6 (4.9) | 0.55 |
| ACLF grade n (%) | 0.26 | ||
| ACLF grade 0 | 17 (28) | 60 (41) | |
| ACLF grade 1 | 11 (18) | 30 (20) | |
| ACLF grade 2 | 9 (15) | 19 (13) | |
| ACLF grade 3 | 23 (38) | 39 (26) | |
| Outcome, n (%) | |||
| Hospital mortality | 20 (33) | 52 (35) | 0.8 |
| Liver transplantation | 5 (8) | 13 (9) | 0.91 |
Significant parameters (p value < 0.05)
IPA invasive pulmonary aspergillosis, COPD Chronic Obstructive Pulmonary Disease, MELD Model of End-Stage Liver Disease, ACLF Acute-On-Chronic Liver Failure, ICU Intensive Care Unit, SAPS II Simplified Acute Physiology Score