Table 2. Logistic regression analysis of associations between SAA1 gene polymorphisms and risk of osteoporosis.
Genotype | Cases (n=300) | Controls (n=350) | OR (95% CI) | P | ||
---|---|---|---|---|---|---|
n | % | n | % | |||
Rs183978373 | ||||||
CC | 225 | 75.0 | 245 | 70.0 | 1.00 | |
CA | 65 | 21.7 | 97 | 27.7 | 0.73 (0.51, 1.05) | 0.088 |
AA | 10 | 3.3 | 8 | 2.3 | 1.36 (0.53, 3.51) | 0.524 |
AA+CA | 75 | 25.0 | 105 | 30.0 | 0.78 (0.55, 1.10) | 0.156 |
CC+CA | 290 | 96.7 | 342 | 97.7 | 1.00 | |
AA | 10 | 3.3 | 8 | 2.3 | 1.47 (0.57, 3.78) | 0.420 |
C allele | 515 | 85.8 | 587 | 83.9 | 1.00 | |
A allele | 85 | 14.2 | 113 | 16.1 | 0.86 (0.63, 1.16) | 0.323 |
Rs12218 | ||||||
TT | 98 | 32.7 | 113 | 32.3 | 1.00 | |
TC | 137 | 45.7 | 187 | 53.4 | 0.85 (0.60–1.20) | 0.343 |
CC | 65 | 21.7 | 50 | 14.3 | 1.50 (0.95–2.37) | 0.083 |
TC+CC | 202 | 67.3 | 237 | 67.7 | 0.98 (0.70–1.36) | 0.918 |
TT+TC | 235 | 78.4 | 300 | 85.7 | 1.00 | |
CC | 65 | 21.7 | 50 | 14.3 | 1.66 (1.11–2.49) | 0.015 |
T allele | 333 | 44.5 | 413 | 59.0 | 1.00 | |
C allele | 267 | 55.4 | 287 | 41.0 | 1.15 (0.93–1.44) | 0.203 |
Rs10832915 | ||||||
TT | 108 | 36.0 | 148 | 42.3 | 1.00 | |
TC | 140 | 46.7 | 158 | 45.1 | 1.21 (0.87, 1.70) | 0.258 |
CC | 52 | 17.3 | 44 | 12.6 | 1.62 (1.01, 2.60) | 0.045 |
TC+CC | 192 | 64.0 | 202 | 57.7 | 1.30 (0.95, 1.79) | 0.102 |
TT+TC | 248 | 82.7 | 306 | 87.4 | 1.00 | |
CC | 52 | 17.3 | 44 | 12.6 | 1.46 (0.94, 2.25) | 0.089 |
T allele | 356 | 40.7 | 554 | 64.9 | 1.00 | |
C allele | 244 | 59.3 | 246 | 35.1 | 1.26 (1.01, 1.58) | 0.041 |
Bold values are statistically significant (P<0.05).