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. 2019 Jan 17;9(2):e01199. doi: 10.1002/brb3.1199

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© 2019 The Authors. Brain and Behavior published by Wiley Periodicals, Inc.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Hypothesized molecular network of cognitive abilities in PedMS. By using the connections between the first genes targeted by at least 6 out of the 11 miRNAs significantly associated with the NPS scores, the following network was composed (Cytoscape software 3.5.1). The node intensity color is proportional to the fold change values (red: under‐regulated; green: up‐regulated); the node size is proportional to the number of miRNA/mRNA connections. Please note that, for this representation, only down‐regulated genes were selected as target of up‐regulated miRNAs and vice versa for down‐regulated miRNAs