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. 2019 Feb 15;39(5):e00405-18. doi: 10.1128/MCB.00405-18

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Copyright © 2019 Minocha et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

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FIG 2 — Hcfc1^hepKO/Y males display increased steatosis. (A) Steatosis was measured by Oil Red O staining of cryosections from control liver (0d) and tamoxifen-treated Alb-Cre-ERT2^tg; Hcfc1^hepKO/Y livers 4, 7, 14, and 18 days after treatment. Dotted lines outline hepatocyte clusters with reduced levels of fat accumulation. Scale bar, 50 μm. (B) Box plots of circulating triglyceride, total cholesterol, and HDL and LDL cholesterol levels in control Hcfc1^lox/Y (n = 6) compared to Alb-Cre-ERT2^tg; Hcfc1^hepKO/Y (n = 6) livers 4 days after tamoxifen treatment. The differences between the levels of triglycerides (P value of 0.02), total cholesterol (P value of 4.2 × 10⁻⁴), and HDL (P value of 4.6 × 10⁻⁴) and LDL (P value of 1.13 × 10⁻⁵) cholesterol in control and knockout livers were significant.