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. 2019 Feb 15;39(5):e00405-18. doi: 10.1128/MCB.00405-18

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Copyright © 2019 Minocha et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

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FIG 7 — Progenitor cell population is activated in Hcfc1^hepKO/Y male livers by 18 days after tamoxifen treatment. Immunofluorescence analyses of paraffin-embedded sections from Alb-Cre-ERT2^tg; Hcfc1^hepKO/Y male livers 18 days after tamoxifen treatment are shown. (A) Staining with DAPI (blue) and HCF-1 antibody (green). Both low and high magnifications of the same section are shown. The arrows point to distinct HCF-1-positive clusters. (B) Staining with DAPI (blue) as well as HNF4α (red) and HCF-1 (green) antibodies. The circle highlights a periportally located HNF4α- and HCF-1-positive hepatocyte cluster. (C) Staining with DAPI (blue) and HCF-1 (green) antibody and, in red, either Ki67 (top), PCNA (middle), or H3S10P (bottom) antibody. Arrows point to Ki67-positive, PCNA-positive, or H3S10P-positve hepatocytes that are also HCF-1 positive. (D) Staining with DAPI (blue) as well as Ki67 (red) and cytokeratin (green) antibodies. White arrows point to periportal Ki67- and cytokeratin-positive cells. The yellow arrow points to a cluster of cells with hepatocyte morphologies. pv, portal vein. Scale bars, 50 μm.