Table 3.
Odds Ratios for HIV+/TB+ Versus HIV+/TB− for Marker Levels Above Median Level of the Total Study Population, Compared to Levels Below Median, With and Without Adjustments for CD4 Cell Counta
| Inflammatory Marker | Crude OR | 95% CI | Adjusted OR | 95% CI | AUC | 95% CI | AUC in Subjects With CD4 <200 Cells/mm3 | 95% CI |
|---|---|---|---|---|---|---|---|---|
| CCL5 | 2.1 | 1.3–3.5 | 2.1 | 1.2–3.4 | 0.62 | 0.55–0.68 | 0.62 | 0.52–0.71 |
| CRP | 8.6 | 4.9–15.1 | 8.0 | 4.5–14.1 | 0.80 | 0.75–0.86 | 0.89 | 0.84–0.95 |
| IL-6 | 5.4 | 3.2–9.3 | 5.0 | 2.9–8.5 | 0.76 | 0.71–0.82 | 0.87 | 0.8–0.93 |
| IL-18 | 3.6 | 2.1–6.1 | 3.1 | 1.8–5.4 | 0.71 | 0.65–0.77 | 0.71 | 0.63–0.8 |
| IP-10 | 2.9 | 1.7–4.8 | 2.5 | 1.5–4.2 | 0.67 | 0.6–0.73 | 0.65 | 0.55–0.75 |
| PCT | 3.1 | 1.9–5.2 | 2.8 | 1.7–4.8 | 0.68 | 0.61–0.74 | 0.73 | 0.64–0.81 |
| suPAR | 4.4 | 2.6–7.4 | 3.9 | 2.3–6.7 | 0.77 | 0.71–0.83 | 0.87 | 0.81–0.93 |
Abbreviations: AUC, area under the curve; CI, confidence intertval; CRP, C-reactive protein; HIV, human immunodeficiency virus; IL, interleukin; IP-10, interferon-γ-induced protein-10; OR, odds ratio; PCT, procalcitonin; suPAR, soluble urokinase-type plasminogen activator receptor; TB, tuberculosis.
a
Area under the curve values are for all markers in whole material and in subjects with CD4 <200 cells/mm3.