Table 1.
Significant and shared KEGG pathways identified from pathway-based analysis of GWAS datasets for MS and IS.
| Classification |
Pathway ID |
Pathway name | IS | MS | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| C | O | E | R | p-value | FDR | C | O | E | R | p-value | FDR | |||
| Immune system | hsa04650 | Natural killer cell mediated cytotoxicity | 135 | 16 | 6.87 | 2.33 | 1.30E-03 | 3.57E-01 | 135 | 15 | 8.81 | 1.70 | 2.93E-02 | 1.39E-01 |
| Immune system | hsa04620 | Toll-like receptor signaling pathway | 106 | 10 | 5.39 | 1.85 | 4.26E-02 | 4.77E-01 | 106 | 14 | 6.91 | 2.02 | 8.62E-03 | 6.58E-02 |
| Immune system | hsa04658 | T1 and Th2 cell differentiation | 92 | 9 | 4.68 | 1.92 | 4.36E-02 | 4.77E-01 | 92 | 20 | 6.00 | 3.33 | 1.33E-06 | 3.65E-04 |
| Drug resistance | hsa01521 | EGFR tyrosine kinase inhibitor resistance | 81 | 10 | 4.12 | 2.43 | 7.65E-03 | 4.29E-01 | 81 | 13 | 5.28 | 2.46 | 2.06E-03 | 2.50E-02 |
| Nervous system | hsa04722 | Neurotrophin signaling pathway | 121 | 13 | 6.16 | 2.11 | 8.27E-03 | 4.29E-01 | 121 | 16 | 7.89 | 2.03 | 5.11E-03 | 4.53E-02 |
| Environmental information processing | hsa04012 | ErbB signaling pathway | 88 | 10 | 4.48 | 2.23 | 1.34E-02 | 4.29E-01 | 88 | 12 | 5.74 | 2.09 | 1.13E-02 | 7.80E-02 |
| Cancers | hsa05214 | Glioma | 66 | 8 | 3.36 | 2.38 | 1.81E-02 | 4.29E-01 | 66 | 9 | 4.30 | 2.09 | 2.65E-02 | 1.30E-01 |
| Environmental Information Processing | hsa04072 | Phospholipase D signaling pathway | 144 | 13 | 7.33 | 1.77 | 3.12E-02 | 4.77E-01 | 144 | 17 | 9.39 | 1.81 | 1.22E-02 | 8.10E-02 |
| Infectious diseases | hsa05161 | Hepatitis B | 146 | 13 | 7.43 | 1.75 | 3.44E-02 | 4.77E-01 | 146 | 19 | 9.52 | 1.99 | 2.87E-03 | 3.03E-02 |
GWAS, large-scale genome-wide association studies; C, the number of reference genes in the category; O, the number of genes in the gene set and also in the category; E, expected number in the category; R, the ratio of enrichment; FDR, false discovery rate; KEGG, Kyoto Encyclopedia of Genes and Genomes.