Table 3.
Results of from pathway-based analysis in IS and MS GWAS datasets showing significant and shared IS-MS pathways in VEGAS in non- redundant GO.
| Gene set | Description | IS | MS | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| C | O | E | R | p-value | FDR | C | O | E | R | p-value | FDR | ||
| BIOLOGICAL PROCESS | |||||||||||||
| GO:0098742 | Cell-cell adhesion via plasma-membrane adhesion molecules | 224 | 25 | 11.40 | 2.19 | 1.89E-04 | 5.66E-02 | 224 | 32 | 13.62 | 2.35 | 5.53E-06 | 1.66E-03 |
| GO:0001562 | Response to protozoan | 21 | 4 | 1.07 | 3.74 | 1.99E-02 | 4.47E-01 | 21 | 5 | 1.28 | 3.92 | 7.39E-03 | 1.20E-01 |
| GO:0010821 | Regulation of mitochondrion organization | 229 | 19 | 11.65 | 1.63 | 2.48E-02 | 4.47E-01 | 229 | 21 | 13.93 | 1.51 | 3.94E-02 | 2.59E-01 |
| GO:0032200 | Telomere organization | 127 | 12 | 6.46 | 1.86 | 2.83E-02 | 4.47E-01 | 127 | 13 | 7.72 | 1.68 | 4.51E-02 | 2.80E-01 |
| GO:0090130 | Tissue migration | 233 | 19 | 11.86 | 1.60 | 2.90E-02 | 4.47E-01 | 233 | 23 | 14.17 | 1.62 | 1.50E-02 | 1.66E-01 |
| GO:0043900 | Regulation of multi-organism process | 267 | 21 | 13.59 | 1.55 | 3.19E-02 | 4.66E-01 | 267 | 26 | 16.24 | 1.60 | 1.20E-02 | 1.49E-01 |
| GO:0034698 | Response to gonadotropin | 27 | 4 | 1.37 | 2.91 | 4.60E-02 | 5.31E-01 | 27 | 5 | 1.64 | 3.05 | 2.17E-02 | 1.90E-01 |
| CELLULAR COMPONENT | |||||||||||||
| GO:0030135 | Coated vesicle | 235 | 21 | 9.82 | 2.14 | 8.26E-04 | 4.79E-02 | 235 | 22 | 11.31 | 1.95 | 2.11E-03 | 8.14E-02 |
| GO:0043292 | Contractile fiber | 209 | 17 | 8.73 | 1.95 | 6.56E-03 | 1.15E-01 | 209 | 16 | 10.06 | 1.59 | 4.45E-02 | 2.13E-01 |
| GO:0000151 | Ubiquitin ligase complex | 287 | 21 | 12.00 | 1.75 | 8.92E-03 | 1.15E-01 | 287 | 22 | 13.81 | 1.59 | 2.06E-02 | 1.83E-01 |
| GO:0030139 | Endocytic vesicle | 254 | 19 | 10.62 | 1.79 | 1.00E-02 | 1.15E-01 | 254 | 22 | 12.22 | 1.80 | 5.42E-03 | 1.05E-01 |
| GO:0019898 | Extrinsic component of membrane | 256 | 19 | 10.70 | 1.78 | 1.09E-02 | 1.15E-01 | 256 | 19 | 12.32 | 1.54 | 3.99E-02 | 2.13E-01 |
| GO:0005798 | Golgi-associated vesicle | 83 | 8 | 3.47 | 2.31 | 2.22E-02 | 1.65E-01 | 83 | 8 | 3.99 | 2.00 | 4.56E-02 | 2.13E-01 |
| GO:0098797 | Plasma membrane protein complex | 222 | 16 | 9.28 | 1.72 | 2.37E-02 | 1.65E-01 | 222 | 22 | 10.68 | 2.06 | 1.01E-03 | 7.84E-02 |
| GO:0042383 | Sarcolemma | 117 | 10 | 4.89 | 2.05 | 2.44E-02 | 1.65E-01 | 117 | 12 | 5.63 | 2.13 | 1.04E-02 | 1.58E-01 |
| GO:0031253 | Cell projection membrane | 292 | 19 | 12.20 | 1.56 | 3.70E-02 | 1.95E-01 | 292 | 23 | 14.05 | 1.64 | 1.36E-02 | 1.58E-01 |
| GO:0034708 | Methyltransferase complex | 93 | 8 | 3.89 | 2.06 | 4.03E-02 | 2.03E-01 | 93 | 10 | 4.47 | 2.23 | 1.36E-02 | 1.58E-01 |
| MOLECULAR FUNCTION | |||||||||||||
| GO:0052813 | Phosphatidylinositol bisphosphate kinase activity | 65 | 10 | 3.01 | 3.32 | 7.47E-04 | 9.12E-02 | 65 | 10 | 3.65 | 2.74 | 3.18E-03 | 9.69E-02 |
| GO:0035004 | Phosphatidylinositol 3-kinase activity | 70 | 10 | 3.24 | 3.09 | 1.35E-03 | 1.10E-01 | 70 | 11 | 3.93 | 2.80 | 1.69E-03 | 7.49E-02 |
| GO:0060090 | Binding, bridging | 176 | 17 | 8.15 | 2.09 | 3.28E-03 | 2.00E-01 | 176 | 19 | 9.89 | 1.92 | 4.71E-03 | 1.05E-01 |
| GO:0008144 | Drug binding | 98 | 11 | 4.54 | 2.43 | 5.51E-03 | 2.69E-01 | 98 | 10 | 5.51 | 1.82 | 4.82E-02 | 2.87E-01 |
| GO:0004386 | Helicase activity | 153 | 14 | 7.08 | 1.98 | 1.14E-02 | 3.99E-01 | 153 | 16 | 8.60 | 1.86 | 1.21E-02 | 1.38E-01 |
| GO:0003713 | Transcription coactivator activity | 294 | 21 | 13.61 | 1.54 | 3.22E-02 | 5.83E-01 | 294 | 26 | 16.52 | 1.57 | 1.47E-02 | 1.43E-01 |
Same conventions as in Table 1.