Comparison 2. Treatment of LE.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Reduction of LE	1	36	Mean Difference (IV, Fixed, 95% CI)	‐39.0 [‐47.37, ‐30.63]
2 Pain score (1‐10 scale)	1	36	Mean Difference (IV, Fixed, 95% CI)	‐4.16 [‐5.17, ‐3.15]
3 Heaviness sensation score (1‐10 scale)	1	36	Mean Difference (IV, Fixed, 95% CI)	‐4.27 [‐5.74, ‐2.80]
4 Function score (1‐10 scale)	1	36	Mean Difference (IV, Fixed, 95% CI)	‐3.77 [‐4.89, ‐2.65]
5 Number of infections per year	1	36	Mean Difference (IV, Fixed, 95% CI)	‐1.22 [0.00, ‐0.44]