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. 2018 Nov 22;47(3):1505–1522. doi: 10.1093/nar/gky1190

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© The Author(s) 2018. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 8. — Schematic summary of this study. Under basal conditions, Meg3 protects DNA from damage independent of PTBP3, while it restrains the expression of p53 target genes in cooperation with PTBP3 likely through interactions with the promoters of p53 target genes. DNA damage induces Meg3 expression via a p53 dependent mechanism. Induced Meg3 is likely involved in restoring the homeostasis of DNA damage response through an unknown mechanism, as indicated by a question mark. Meg3 knockdown leads to DNA damage and ATM activation, which in turn stabilizes p53 by disrupting p53 and MDM2 interaction. Activation of p53 signaling results in the expression of p53 target genes, EC apoptosis, and decreased EC proliferation. PTBP3 knockdown phenocopies Meg3′s effects on the activation of p53 signaling, the expression of p53 target genes, EC apoptosis, and decreased EC proliferation.