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. 2018 Nov 22;47(3):1493–1504. doi: 10.1093/nar/gky1187

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© The Author(s) 2018. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 6. — The ‘scaffolding’ component in the trypanosomatid cap-binding complex is eIF4E4. (A) The structural data and quantitative interaction measurements reported here demonstrate that Leishmania eIF4E4 (E) engages in specific interactions (continuous edges in the interaction graph) with PABP1 (P) and with eIF4G3 (G), whereas there was no detectable interaction between PABP1 and eIF4G3. The known interactions between PABP1 and poly(A), and between eIF4E4 and the cap4 (5′C⁴) structure, complete the map of the eIF4G3–eIF4E4(cap4)-PABP1-poly(A) biomolecular chain. (B) In all other known eukaryotic cap-binding complexes, the core scaffolding protein is eIF4G, as reflected in this interaction map.