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. 2018 Dec 8;47(3):1070–1081. doi: 10.1093/nar/gky1232

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© The Author(s) 2018. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — Synthesis and biophysical characterization of lipid-hsiRNA conjugates. (A) Chemical structures of lipid-hsiRNA conjugates. (B) Modification pattern and molecular model of lipid-hsiRNAs. (C) HPLC traces of lipid-hsiRNAs following reverse phase column chromatography. (D) HeLa cells were incubated with PPIB-targeting hsiRNAs at concentrations shown for 72 h. PPIB mRNA levels were measured using QuantiGene (Affymetrix), normalized to housekeeping HPRT1 (hypoxanthine phosphoribosyltransferase 1) mRNA levels, and presented as percent of untreated control (n = 3, mean ± SD). UNT – untreated cells. (E) Plotted IC₅₀ values determined from the best-fit curves in (D).