Table 1.
Risk factor | Local or systemic? | Proposed mechanism of risk |
---|---|---|
Dietary caloric intake | Systemic | Hyperglycemia |
Hyperglycemia | Systemic | Cell hyperproliferation |
Obesity | Systemic | History of hyperglycemia |
Chronic inflammation | Both | History of energy oversupply |
The right-most column summarizes the proximal causal mechanisms we propose in this article.