Fig. 1.

MRI pulse sequences usually used in a clinical setting. T1-w provides an anatomical reference and T2-w is used for WM lesions visualization. However, on the T2-w, periventricular lesions are often indistinguishable from the adjacent CSF, which is also of high signal. WM lesions (red rectangles) characteristic of MS are best seen on the FLAIR pulse sequence because of the suppression of the ventricular signal. DIR has direct application in MS for evaluating cortical pathology. PD and T1SE are also used clinically. (Note: for interpretation of the references to color in this figure legend, the reader is referred to the online version of this article.)