Table I.
Inclusion criteria for the 2 active surveillance protocols at the National Cancer Institute in Milan
| SAINT | PRIAS | |
|---|---|---|
| PSA, ng/mL | ≤10 | <10 |
| Clinical stage | T1c and T2a; T1b if cancer ≤0.5 cm3 and negative biopsies of the peripheral zone | ≤T2c |
| GPS | 3 + 3 | 3 + 3 or 3 + 4 in age >70 years, tumor involving <10% core length |
| Number of positive cores | ≤20% of all cores until December 2011; ≤25% of all cores since December 2011 | ≤2 or ≤15% of all cores in case of saturation biopsy (>20 cores) with a maximum of 4 |
| PSA density | / | <0.2 ng/mL/cm3 |
| Core involvement | ≤50% of core involvement | / |
GPS = Gleason Pattern Score; PRIAS = Prostate Cancer Research International: Active Surveillance; PSA = prostate-specific antigen; SAINT = Sorveglianza Attiva Istituto Nazionale Tumori.